منابع مشابه
Heart antibodies in cardiomyopathies.
The reported frequency of circulating heart reactive antibodies in cardiomyopathies has varied and their significance is unknown. In this study such antibodies were sought in patients with primary congestive and hypertrophic cardiomyopathies and other heart diseases. Standard "single sandwich" and the more sensitive "double sandwich" indirect immunofluorescence techniques failed to disclose a s...
متن کاملCardiomyopathies and heart failure
Primary heart failure in cardiomyopathy occurs in (1) hypertrophic cardiomyopathy, a genetic disease of the sarcomere; and (2) in dilated cardiomyopathy. The latter is often regarded as idiopathic in origin, but requires exclusion of all possible etiologies which are becoming easier to identify with modern investigative techniques. Tachycardia-induced cardiomyopathy is now increasingly recogniz...
متن کاملGenetic cardiomyopathies causing heart failure.
Despite the striking advances in medical and surgical therapy, the morbidity, mortality, and economic burden of heart failure (HF) remain unacceptably high. There is increasing evidence that the risk and course of HF depend on genetic predisposition; however, the genetic contribution to HF is heterogeneous and complex. At one end of the spectrum are the familial monogenic HF syndromes in which ...
متن کاملThe ubiquitin proteasome system in human cardiomyopathies and heart failure.
Maintenance of protein quality control is a critical function of the ubiquitin proteasome system (UPS). Evidence is rapidly mounting to link proteasome dysfunction with a multitude of cardiac diseases, including ischemia, reperfusion, atherosclerosis, hypertrophy, heart failure, and cardiomyopathies. Recent studies have demonstrated a remarkable level of complexity in the regulation of the UPS ...
متن کاملActivating beta-1-adrenoceptor antibodies are not associated with cardiomyopathies secondary to valvular or hypertensive heart disease.
OBJECTIVES We investigated whether autoantibodies against the human beta-adrenergic receptor (beta-AR) might be involved in cardiomyopathies secondary to valvular heart disease (VHD) or hypertensive heart disease (HHD). BACKGROUND Autoimmunity to beta-AR has been proposed as a pathogenic principle in human cardiomyopathy. Recently, by the use of intact recombinant human beta-AR, we were able ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Heart
سال: 1981
ISSN: 1355-6037
DOI: 10.1136/hrt.46.3.296